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N Taleboo, M Gudi, N Robertson, P Wang
Magnetic particle imaging (MPI) is a new imaging modality with the potential for high-resolution imaging while retaining the noninvasive nature of other current modalities such as magnetic resonance imaging (MRI) and positron emission tomography (PET). It is able to track location and quantities of special superparamagnetic iron oxide nanoparticles without tracing any background signal. MPI utilizes the unique, intrinsic aspects of the nanoparticles: how they react in the presence of the magnetic field, and the subsequent turning off of the field. The current group of nanoparticles that are used in MPI are usually commercially available for MRI. Special MPI tracers are in development by many groups that utilize an iron-oxide core encompassed by various coatings. These tracers would solve the current obstacles by altering the size and material of the nanoparticles to what is required by MPI. In this review, the theory behind and the development of these tracers are discussed. In addition, applications such as cell tracking, oncology imaging, neuroimaging, and vascular imaging, among others, stemming from the implementation of MPI into the standard are discussed.

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Magnetic Insight, leader in Magnetic Particle Imaging (MPI), represents one of the most powerful approaches to preclinical imaging in the last 20 years with translation to the clinic. MPI harnesses nanotechnology in imaging and therapy with a direct bridge to the complete cell therapy workflow and development.