Super-Paramagnetic Iron Oxide (SPIO) Tracers For Preclinical MPI

VivoTrax Plus

VivoTrax Plus is an MPI optimized version of VivoTrax with triple the signal and improved resolution.  These properties improve sensitivity to smaller numbers of labeled cells and enhance the quality of the MPI images.


VivoTrax is one of the few tracers proven for MPI and is commonly used in MPI and MRI research due to its similarity to clinically approved SPIO tracers. The dextran magnetite solution is well characterized and has a long history in imaging. VivoTrax is frequently used to track cells in vivo.

VivoTrax & VivoTrax Plus

VivoTrax & VivoTrax Plus are available from Magnetic Insight in 5-tube packages. Each vial contains 1.1 mL of VivoTrax superparamagnetic iron oxide (SPIO) dextran magnetite nanoparticle solution, comprising ~5.5 mg/mL total iron and ~6 mg/mL carboxydextran in sterilized PBS. Endotoxins <0.5 EU/mg Fe.

Left: Vivotrax, Right: Prussian blue staining of mesenchymal stem cells labeled with VivoTrax,
Bottom: Tracking I.V. injected mesenchymal stem cells. (
Zheng et al. Theranostics, 2016)