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HYPER: In Vivo Localized Magnetic Theranostic Platform

HYPER is the first commercially available localized, image-guided magnetic fluid hyperthermia (MFH) system for small animals. Using magnetic gradients for localization like magnetic particle imaging (MPI), the HYPER technology produces localized heating of nanoparticles within a sensitive region known as the Field-Free Region (FFR).

The FFR can be adjusted in both size and position, which, in conjunction with RF amplitude adjustment, allows the user control of heating to millimeter-scales along with real-time fiber optic temperature monitoring. HYPER is a ground-breaking research tool for magnetic thermal ablation, drug release, and cell activation models.

HYPER is available as a stand-alone system that can be integrated with the MOMENTUMTM Magnetic Particle Imaging (MPI) workflow or other tomographic imaging modalities such as optical, PET, MRI and X-ray/CT.

HYPER Workflow

Seamless Integration and Controls for Localized Treatment Planning

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Load Image with target of interest
Transfer subject into the HYPER system along with DICOM file to target desired therapeutic area.

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Identify and target
Define localized regions to perform therapeutic hyperthermia and estimate temperature parameters.

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Monitor and quantify
Monitor localized hyperthermia with temperature probes during the length of therapeutic course. 

Features

  • Mouse transport bed with fiducials
  • Biplanar optical cameras registration
  • Simple co-registration to MPI MOMENTUM images
  • Supports co-registration of imported DICOM formats of most imaging modalities.
  • Real time fiber optic temperature sensors for monitoring (two channels)
  • Software controls for pulsed treatment sequences

Specifications

  • Bore size: 4 cm (maximum diameter of animal and carriage)
  • Available heating area: 4 x 4 x 10 cm
  • Field gradient: Variable selection from 0.5 T/m to 2.0 T/m
  • Radio Frequency: Field selection from 340 kHz to 20 mT continuous
  • Weight: 400 kg (882 lbs)
  • Width of 1.5 m (60 inches)
  • Depth of 1.5 m (60 inches)
  • Height of 2.0 m (79 inches)

Site Requirements

  • Simple 120V/ 230V single phase electrical power input
  • Area to accommodate instrument footprint