HYPER Header Image

HYPER: In Vivo Localized Magnetic Theranostic Platform

HYPER is the first commercially available localized, image-guided magnetic fluid hyperthermia (MFH) system for small animals. Using magnetic gradients for localization like magnetic particle imaging (MPI), the HYPER technology produces localized heating of nanoparticles within a sensitive region known as the Field-Free Region (FFR).

The FFR can be adjusted in both size and position, which, in conjunction with RF amplitude adjustment, allows the user control of heating to millimeter-scales along with real-time fiber optic temperature monitoring. HYPER is a ground-breaking research tool for magnetic thermal ablation, drug release, and cell activation models.

HYPER is available as a stand-alone system that can be integrated with the MOMENTUMTM Magnetic Particle Imaging (MPI) workflow or other tomographic imaging modalities such as optical, PET, MRI and X-ray/CT.

HYPER Workflow

Seamless Integration and Controls for Localized Treatment Planning

Click to enlarge

Load Image with target of interest
Transfer subject into the HYPER system along with DICOM file to target desired therapeutic area.

Click to enlarge

Identify and target
Define localized regions to perform therapeutic hyperthermia and estimate temperature parameters.

Click to enlarge

Monitor and quantify
Monitor localized hyperthermia with temperature probes during the length of therapeutic course. 

Features

  • Mouse transport bed with fiducials
  • Biplanar optical cameras registration
  • Simple co-registration to MPI MOMENTUM images
  • Supports co-registration of imported DICOM formats of most imaging modalities.
  • Real time fiber optic temperature sensors for monitoring (two channels)
  • Software controls for pulsed treatment sequences

Specifications

  • Bore Size: 72 mm
  • Available heating: 7.2 x 7.2 x 12 cm
  • Field gradient : Variable selection from 0.5 to 2.0 T/m
  • Heating ROI: 1.06 cm3 to  43.2 cm3 (using Synomag-D 70nm, micromod.de )
  • Radio Frequency: approximately 350 kHz at 0 to 20 mT amplitude
  • Temperature monitoring : fiber optic, 2 channels.
  • Weight: 460 kg (1012 lbs)
  • Width of 1.5 m (60 inches)
  • Depth of 0.8 m (32 inches)
  • Height of 1.8 m (70 inches)
  • Single- or dual-phase input at 208-240 V, 30 A