Cell Therapy and Tracking

Cellular therapy is rapidly expanding within modern medicine; with numerous applications in both regenerative medicine and immunotherapy. Treatment relies on the specialization and modification of cells in vitro, which are administered into a patient to treat a specific target. While experimental results have shown that cellular therapy can be successful, the field has struggled to produce consistent clinical results. One barrier arises in that it can take months before diagnostic feedback and if the cells are providing any therapeutic benefit.

With Magnetic Particle Imaging, cell tracking reveals the in vivo fate of these therapeutic cells. Learn more about cell therapy and tracking using Magnetic Particle Imaging. 

Nanoparticle Technology

 
Nanoparticles have been used in research and medicine for decades and not until recently, has the community been able to truly accelerate their utility for monitoring functional events within the body and as therapeutic tools. Nanoparticles as contrast agents and tracers are simple and safe option for imaging workflows. With the introduction of magnetic particle imaging, ordinary particle tracers have the ability to expose therapeutic workflows in cell treatments, monitoring inflammation and vascular perfusion in a quantitative format without radiation.
 

Learn more about particle design for Magnetic Particle Imaging applications. 

Quantitative Inflammation

Magnetic nanoparticles can be loaded into a variety of cells (such as, monocytes and other leukocytes) and those cells tracked as they migrate and accumulate within the region of inflammation. The nanoparticles can also be directly injected, where they are captured by phagocytotic immune cells, which also home to the site of inflammation. Using Magnetic Particle Imaging, these regions of inflammation can be tracked for days to weeks.

 

Localized Magnetic Theranostics


Theranostic hyperthermia treatment is delivered using the same nanoparticle tracers as Magnetic Particle Imaging. Magnetic Fluid Hyperthermia is performed by only heating tracers present in the field free region. This ensures treatment is localized to the specific region of interest, preventing off-target tissue damage. HYPER™ enables image-guided dose planning and treatment contouring with millimeter accuracy.

Learn more about Localized Magnetic Theranostics.