Magnetic Particle Imaging in Research
MPI is the first molecular imaging technique simultaneously capable of: nanomolar sensitivity, absolute quantitation, resolution independent of depth, and with tracer detection from weeks to months.
MPI is Fundamentally a Molecular Imaging Technique
MPI is complementary to existing molecular imaging techniques, giving scientists a versatile new tool when working with cancer imaging, cell tracking, and angiography.
For the first time, scientists will be able to see less than 100 tagged cells and track them anywhere in body. MPI is able to harness the longevity of SPIO nanoparticles as a vascular or functional tracer, enabling imaging models that can quantitatively track disease development over time. These ground-breaking attributes will accelerate cell therapy research (Figure 2).
|Functional Imaging||Anatomical Imaging|
|Deep Tissue Imaging|
|< 100 cell sensitivity at any
depth, key for cell tracking
|Vascular, functional and
cell based technologies
|Translatable to the clinic|
|Exquisite resolution (≤ 1 mm)|
|Long term tracer stability|
MPI is a positive contrast modality and measures an absolute linear quantitation of SPIO particles regardless of depth. This is key to longitudinal and reproducible data.
Ease of Use
MPI has the ease of use and workflow similar to optical imaging based on its speed and application workflow. MPI can image in milliseconds, supporting real-time imaging applications in cardiovascular and perfusion research at depths exceeding ultrasound’s abilities. The MPI workflow is straightforward and has simple acquisition settings to acquire quantitative data (i.e., no pulse sequences or radio).
The strength of MPI lies in the flexibility, safety, and longevity of its tracers. For decades, researchers have worked with nanoparticles in MRI and CT, and many groups have demonstrated nanoparticles targeting inflammation, atherosclerotic plaques, and cancers, among others. MPI can perform these same experiments, but with greater contrast, sensitivity, and quantitation over MRI and CT. MPI tracers are also safe and translatable. Clinically approved iron oxide tracers are also available.