Publications

Webinar Presentations

Webinar: The Basics of Magnetic Particle Imaging

Recorded Presentation Here

This presentation will introduce a ground-breaking, next generation imaging technology called magnetic particle imaging (MPI). We will review the basic theory behind MPI along with current and future application opportunities.

Webinar: Preclinical Applications in Magnetic Particle Imaging

Recorded Presentation Here

This presentation will introduce magnetic particle imaging (MPI) and current applications in preclinical imaging. MPI is the first molecular imaging technique simultaneously capable of: nanomolar sensitivity, absolute quantitation, resolution independent of depth, and with tracer detection from weeks to months. MPI is complementary to existing molecular imaging techniques, giving scientists a new versatile tool to accelerate cancer, infectious disease, cell tracking, and vascular research.

Webinar: Nanoparticle Development for Magnetic Particle Imaging Applications

Recorded Presentation Here

MPI is a revolutionary technique for imaging iron oxide tracers with high sensitivity and contrast. This presentation will be co-hosted by Magnetic Insight and LodeSpin Labs.

LodeSpin Labs is developing a suite of high-performance MPI-optimized nanoparticles. These unique nanoparticles start as iron oxide cores for maximum SNR and resolution. Added functional, biocompatible coatings extend blood circulation and support conjugation chemistry for a variety of applications. LS-008, LodeSpins Lab’s blood pool tracer, circulates for hours in mice, greatly enhancing the MPI imaging window and improving SNR and resolution compared with standard SPIO tracers.

Additionally, Magnetic Insight will discuss the versatility of available SPIO’s to support applications in cell tracking, functional targeting and interventional imaging.

 

Journal Publications

  • Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In Vivo. B Zheng et al., Theranostics, 2016; 6(3): 291-301.
  • Low drive field amplitude for improved image resolution in magnetic particle imaging. LR Croft et al, Medical Physics, 43.1 (2016): 424-435.
  • Magnetic nanoparticles: material engineering and emerging applications in lithography and biomedicine. Y Bao et al., Journal of Materials Science, 51.1 (2016): 513-553.
  • A Convex Formulation for Magnetic Particle Imaging X-Space Reconstruction. JJ Konkle, PW Goodwill, DW Hensley, RD Orendorff, M Lustig, SM Conolly, PLoS One, 2015 Oct 23;10(10):e0140137. doi: 10.1371/journal.pone.0140137. eCollection 2015.PMID: 26495839. Free Article.
  • Lactoferrin conjugated iron oxide nanoparticles for targeting brain glioma cells in magnetic particle imaging. A Tomitaka, H Arami, S Gandhi, KM Krishnan, Nanoscale, 2015 Oct 8;7(40):16890-8. doi: 10.1039/c5nr02831k. PMID: 2641261.
  • Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast. B Zheng, T Vazin, PW Goodwill, A Conway, A Verma, E Ulku Saritas, D Schaffer, SM Conolly, Sci Rep, 2015 Sep 11; 5:14055. doi: 10.1038/srep14055.PMID: 26358296. Free PMC Article.
  • Magnetic Particle Imaging Tracers: State-of-the-Art and Future Directions. LM Bauer, SF Situ, MA Griswold, AC Samia, J Phys Chem Lett, 2015 Jul 2;6(13):2509-17. doi: 10.1021/acs.jpclett.5b00610. Epub 2015 Jun 17. PMID: 26266727.
  • Effects of pulse duration on magnetostimulation thresholds. EU Saritas, PW Goodwill, SM Conolly, Med Phys, 2015 Jun;42(6):3005-12. doi:10.1118/1.4921209. PMID: 26127053
  • Usefulness of Magnetic Particle Imaging for Predicting the Therapeutic Effect of Magnetic Hyperthermia. K Murase, M Aoki, N Banura, K Nishimoto, A Mimura, T Kuboyabu, I Yabata, Open Journal of Medical Imaging, 2015. Free Article.
  • Linearity and Shift-Invariance For Quantitative Magnetic Particle Imaging. K Lu, PW Goodwill, EU Saritas, B Zheng, SM Conolly, IEEE Transactions on Medical Img, 32(9), 2013.
  • Projection Reconstruction Magnetic Particle Imaging. JJ Konkle, PW Goodwill, O Carrasco-Zevallos, SM Conolly, IEEE Trans Med Img, 32(2), 2013.
  • Magnetic Particle Imaging (MPI) for NMR and MRI Researchers. EU Saritas, PW Goodwill, LR Croft, JJ Konkle, K Lu, B Zheng, SM Conolly, Journal of Magnetic Resonance, 229, 2013.
  • Magnetostimulation Limits in Magnetic Particle Imaging. EU Saritas, PW Goodwill, GZ Zhang, SM Conolly, IEEE Trans Med Img, 32(9), 2013.
  • Twenty-fold acceleration of 3D projection reconstruction MPI. JJ Konkle, PW Goodwill, EU Saritas, B Zheng, K Lu, SM Conolly, Biomedizinische Technik/Biomedical Engineering, 58(6), 565-76, 2013.
  • X-space MPI: Magnetic Nanoparticles for Safe Medical Imaging. W Goodwill, EU Saritas, LR Croft, TN Kim, KM Krishnan, DV Schaffer, SM Conolly, Advanced Materials, 24 (28), 3870-3877, 2012.
  • Projection X-Space Magnetic Particle Imaging. PW Goodwill, J Konkle, B Zheng, S Conolly, IEEE Trans Med Img, 31(5), 1076-85, 2012.
  • An X-Space Magnetic Particle Imaging Scanner. PW Goodwill, K Lu, B Zheng, S Conolly, Review of Scientific Instruments, 83, 033708, 2012.
  • Relaxation in X-Space Magnetic Particle Imaging. L Croft, PW Goodwill, SM Conolly, IEEE Trans Med Img, 31(12), 2012.
  • Multidimensional X-space Magnetic Particle Imaging. PW Goodwill, SM Conolly, IEEE Trans Med Img, 30(9), 2011.
  • First phantom and in vivo MPI images with an extended field of view. I Schmale, J Rahmer, B Gleich, J Kanzenbach, JD Schmidt, C Bontus, O Woywode, J Borgert, Proceedings of SPIE, 7965, 796510—796510-6, 2011.
  • Optimizing magnetite nanoparticles for mass sensitivity in magnetic particle imaging. RM Ferguson, KR Minard, AP Khandhar, and KM Krishnan, Medical Physics, 38(3), 1619, 2011.
  • Ferrohydrodynamic Relaxometry for Magnetic Particle Imaging. PW Goodwill, A Tamrazian, LR Croft, CD Lu, EM Johnson, R Pidaparthi, RM Ferguson, AP Khandhar, KM Krishnan, and SM Conolly, Applied Physics Letters, 98, 262502, 2011.
  • Magnetic Particle Imaging process: One-Dimensional Signal, Bandwidth, SNR, and SAR. PW Goodwill, SM Conolly, IEEE Trans Med Img, 29(11), 2010.
  • Narrowband Magnetic Particle Imaging. PW Goodwill, G Scott, P Stang, SM Conolly, IEEE Trans Med Img, 28(8), 1231-7, 2009.
  • Three-dimensional real-time in vivo magnetic particle imaging. J Weizenecker, B Gleich, J Rahmer, H Dahnke, J Borgert, Phys Med Biol, 54(5):L1-L10, 2009.
  • Optimization of nanoparticle core size for magnetic particle imaging. RM Ferguson, KR Minard, and KM Krishnan, J. Magn Magn Mater, 321 (10), 1548–1551, 2009.
  • Signal encoding in magnetic particle imaging: properties of the system function. J Rahmer, J Weizenecker, B Gleich, and J Borgert, BMC Medical Imaging, 9(1), 2009.
  • Tomographic imaging using the nonlinear response of magnetic particles. B Gleich and J Weizenecker, Nature, 435 (7046), 1214–7, 2005.

 

Video Presentations


June 8, 2012. A big obstacle to developing stem cell therapies is being able to visualize the cells inside the body. This will be critical to confirm that the stem cells are targeted to the right place and are providing therapeutic benefit. Current imaging technology is not adequate for tracking stem cells in vivo.


March 23, 2013. The International Workshop on Magnetic Particle Imaging (IWMPI) is the premier forum for researchers working in the field of Magnetic Particle Imaging (MPI). The 3rd IWMPI took place at University of California, Berkeley on March 23-24, 2013. This video includes the opening remarks by Prof. Steven M. Conolly, the workshop chair.